Launched in 2011, Saving Lives at Birth (SL@B) was a partnership of key global health stakeholders that funded a total of 147 innovations from 92 organizations addressing critical issues in maternal and newborn health (MNH) in low-resource settings. Two funding partners from SL@B engaged Duke GHIC in 2018 to design and conduct an evaluation of the program to determine if it was achieving its intended impact in addressing MNH outcomes and to generate data-driven recommendations for future initiatives. The Duke GHIC Evaluating SL@B (ESL@B) research team and their collaborators designed an evaluation around key evaluation questions, informed by the original call for proposals and SL@B’s theory of change. The team produced several reports including portfolio analysis and cost-effectiveness analyses to the SL@B partners, while also sharing data-driven recommendations for this and other similar programs in the future.