Rwanda’s Ministry of Health leveraged COVID-19 resources, established through the QuickStart COVID-19 Test-and-Treat Initiative, to respond to the Marburg Virus Disease (MDV) and Claude 1b Mpox outbreak. The Ministry of Health invited the QuickStart team in Rwanda to support various response efforts including development of guidelines and standard operating procedures, supply chain management and strengthening the capacity of healthcare workers to respond to the outbreaks. QuickStart investments have contributed to Rwanda’s health system resilience and pandemic preparedness capacity underscoring the importance of building sustainable investments for resilient health systems.